Base on Wheels: The second act gives you a quest to obtain the Ursula, a land train that serves as your mobile base from that point on.
Although you cannot take it with you into the open world afterwards, the servoshell makes the area much easier due to the high protection it affords you as well as a great boost to strength allowing you to bash open locks you might not be able to pick just yet.
A Taste of Power: In your first dungeon, the last area before you get into the open world, you are given a Mark III Servoshell.
She paints her faction in the worst light, being obstructive and quarrelsome. Even the warlike Phalanx is at most rather laconic. While her job is to defend Carmine Height's interests, her personality is in stark contrast with most of the other representatives who are civil at the very least. That is, the Dome's only hope at the moment. Especially the player character even after it is proved that this individual might be the only person alive who can use the Emulator Project to move the Maelstrom.
"Ass" in Ambassador: Carmine Height's representative to the Council, Karma Ishtwani, is openly rude and almost hostile to just about everybody.
Assimilation Plot: The Maelstrom aims to unify all human minds, in one and only mind, creating a "common Consciousness" or a "collective consciousness".
Archaeological Arms Race: Conducted first by the CRONUS Foundation to control and dominate the technologies of the Forefathers inside the Dome, then directly the major world powers after the awakening of the Maelstrom.
The awakening of Maelstrom, however, had led to the situation rapidly evolving, to the point a nuclear war occurred while the protagonist was trapped inside the "mental sphere". It started a reconciliation between the United States of America and the Soviet Union, as they put aside their rivalries to create the CRONUS Foundation in order to explore The Dome and exploit the alien technologies inside it, which led to a new scientific revolution.
Alternate History: The discovery of The Dome in 1971 had led to the end of the Vietnam War and by extension, the Cold War.
That being said there is an amount of ventilation shafts that don't warrant being able to move through.
Air-Vent Passageway: Mostly justified as not only are they general maintance tunnels with electrical, steam, and water systems running along them, but being underground bunkers they have to be that large to move enough air through them.
Also the various Androids you fight, though that's said to be programming corruption caused by the Maelstrom.
Is a Crapshoot: The Maelstrom, the alien artificial intelligence created by the Forefathers, to serve and help the latter, an advanced and advanced artificial intelligence beyond any imagination, which had rebelled against the Forefathers, then accidentally awakened by the protagonist, causes the devastation of the world and of the human race.
Agonizing Stomach Wound: One person in the Nashville facility is washing the floor, with his own disemboweled intestines.
Advanced Ancient Acropolis: The ruins of the ancient and mysterious cities of the Forefathers inside the Dome.
Your character's intelligence is rock bottom but you get a wide array of very beneficial abilities as you climb the skill trees.
Achievements in Ignorance: The "As a Bag of Hammers" quirk.
The "A Thousand and One Deaths" achievement requires you to get all the achievements mentioned above.
The "Wrong Turn" achievement requires you to behave in a stupid manner, leading to you crashing a hijacked car and dying.
The "Like a Cockroach" achievement requires you to fail attribute/skill checks when riding a certain elevator resulting in death and game over.
"Getting Hot in Here" for getting inside the empty coffin and getting cremated.
"Changed My Mind" is gained for taking an opportunity to leave the Dome via Concord cargo lift, with spectacularly gory results.
The "Wake Up!" achievement requires you to fail the main quest by skipping time in Concord Station, thus netting you a death and game over.
It mentions that the Magellan sewage system is absurdly spacious because it's an emergency exit route.
Absurdly-Spacious Sewer: Justified in the loading blurb for the residential district.